Ph.D. Thesis Proposal Defense - Deborah Jacob
Title: Quantifying Postural control in neurodegenerative disease using BioVrSea paradigms
Candidate: Deborah Jacob
Supervisor: Paolo Gargiulo, Reykjavík University
Thesis committee: Hannes Petersen, Maria K Jónsdóttir and Mahmoud Hassan
Research council: Jónas Þ Snæbjörnsson, Direct
Monday January 23, 14:30 - 15:00 room M208
Abstract: Parkinson’s Disease is among the most prevalent neurological diseases in the world today. Typically characterised by impairments in motor function, there remains no known cure for the disease. Treatments generally take the form of medication and/or surgical intervention in combination with physical therapy. Deficits in postural control are commonly seen in Parkinson’s sufferers. Our work using the unique BioVRSea setup aims to assess early-stage Parkinson’s using a combination of neurophysiological (Electromyography and Heart Rate) and centre of pressure (or sway) measurements. 11 early-stage Parkinson’s subjects and 46 healthy over-50s took part in the experiment. Significant differences were found between the two groups in electromyographic and centre of pressure measurements. Correlation analysis indicated opposite correlations in skewness in the right soleus muscle. Finally, machine learning was able to predict with a maximum of 94.6% accuracy whether a subject belonged to the healthy or Parkinson’s group based on their measurements from the experiment. Our results are a first step in a prototype of the quantitative evaluation of early-stage Parkinson’s
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Meeting ID: 684 0431 9194
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Meeting ID: 684 0431 9194
