PhD defense in the School of Science and Engineering

Genetic Epidemiology of Cancer in Romania

  • 20.9.2018, 14:00 - 16:00

The PhD defense of Paul Iordache will be held on Thursday the 20th of  September at 14:00 in room M325.   

Title of thesis: Genetic Epidemiology of Cancer in Romania

Candidate: Paul Daniel Iordache

Field: Applied Biostatistics

Date and time: 20th of September 2018 at 14:00

Room: M325

Supervisor: Bjarni Halldórsson (Reykjavik University)

Examiner: Kathleen C. Barnes (University of Colorado) Committee members:  Þórunn Rafnar (Decode Genetics), Andrei Manolescu (Reykjavik University)


In Romania, there is a lack of quantitative data associating the cancer risk with genetic characteristics. The aim of the present thesis is to evaluate the genetic risk factors associated with two major cancer types (prostate cancer and colorectal cancer). The first outcome is to determine the profile of common prostate cancer risk variants in the Romanian population. The second outcome is the identification of high-risk mutations in colorectal cancer genes associated with Lynch Syndrome. Early diagnosis and treatment are key factors in determining the evolution and survival of cancer patients. Genetic variants that can determine which early stage tumours will progress to an aggressive form of the disease can change decision making for clinicians, patients, and their families. If genetic findings are to be translated into clinical utility, it is vital to understand the particularities of genetic epidemiology of cancer in Romania.